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-synuclein, that's a major element of Lewy bodies, in PARK 1 in 1997 and parkin in PARK 2 in 1998, which happens to be an E3 ubiquitin ligase and causes endoplasmic reticulum (ER) worry, counsel that dysfunction with the intracellular proteinase units, such as ubiquitin-proteasome system or lysosomal procedure, which gets rid of unneeded harmful pr